Lobular Breast Cancer: Common Problems in Diagnosing LCIS in Core Needle Biopsies
نویسنده
چکیده
Lobular carcinoma in situ (LCIS) of the breast may exhibit a spectrum of morphologic growth patterns and may also colonize underl ying benign breast lesions. This diversity in appearance can create diagnostic challenges, especially in core needle biopsy specimens. Some LCIS variants may mimic ductal carcinoma in situ or invas ive carcinoma. Furthermore, some LCIS variants are frequently associated with adjacent invasive lobular carcinoma. Therefore, familiarity with this morphologic spectrum is essential when eva luating LCIS in core needle biopsies. This review focuses on histologic and immunohistochemica l features that help to distinguish unusual patterns of LCIS from the lesions they mimic.
منابع مشابه
Anatomic Pathology / LOBULAR NEOPLASIA IN BREAST CORE NEEDLE BIOPSY SPECIMENS Lobular Neoplasia in Breast Core Needle Biopsy Specimens Is Not Associated With an Increased Risk of Ductal Carcinoma In Situ or Invasive Carcinoma
Recent reports suggest that the finding of lobular neoplasia (atypical lobular hyperplasia [ALH] or lobular carcinoma in situ [LCIS]) in breast core needle biopsy specimens may be associated with an increased risk of both ductal carcinoma in situ (DCIS) or invasive carcinoma at excision. We reviewed our breast core biopsy material to see if we could confirm this finding. From 4,297 biopsies, 71...
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